BI110 Chapter Notes - Chapter 26: Acetyl-Coa, Pyruvate Dehydrogenase, Oxidative Phosphorylation

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16 Dec 2015
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Module 26: the citric acid cycle and oxidative phosphorylation. Most energy is harvested after pyruvate is completely oxidized: this is accomplished in the later stages of cellular respiration: pyruvate decarboxylation, the citric acid cycle, and oxidative phosphorylation. The two molecules of pyruvate from glycolysis must be transported to the matrix. Three enzymes of the pyruvate dehydrogenase catalyze the conversion of each three-carbon pyruvate molecule into two molecules. Pyruvate is decarboxylated; its carboxyl group is removed as a one-carbon molecule of carbon dioxide, which diffuses out of the mitochondria and out of the cell. The remaining two-carbon acetyl group is then transferred to the small molecule coenzyme a to form acetyl coenzyme a: conversion is exergonic. Some of the released energy is captured by the reduction of nad+ to nadh; the remaining energy is released as heat. Some chemical energy is harvested in acetyl-coa and transferred to several different molecules for use in oxidative phosphorylation.

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