Pathology 2420A Chapter Notes - Chapter 5: Cancer, Anaplasia, Hamartoma
11 Dec 2017
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Parenchyma , made up of transformed or neoplastic cells. The stroma is important for the growth of the neoplasm: benign tumors. In some cases, tumor cells undo divergent differentiation mixed tumors they are still monoclonal but the progenitor cells has the capacity to differentiate down more than one lineage. For example, a small nodule of well developed and normally organized pancreatic tissue may be found in mucosa of stomach or intestine. Differentiation is the extent to which neoplasms resemble their parenchymal cells of origin, both morphologically and functionally ; lack of differentiate is called anaplasia. In benign well-differentiate cells that look like their normal counterparts so lipoma is made up of mature fat cells. Malignant neoplasm wide range of parenchymal cell differentiation, most of which exhibit morphologic alterations e. g. variation in cell and nuclear size. Dysplastic epithelium is recognized by a loss in the uniformity of individual cells and in their architectural orientation: local invasion.
