Biology 2290F/G Chapter Notes -Colchicine, Hitchhiking, Stathmin
3 Mar 2014
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Wednesday february 6th & monday february 11th, 2013. Both the cellular trafficking of organelles and cell migration are achieved using the cytoskeleton. The cytoskeleton is an intricate network of protein filaments that extend throughout the cytoplasm. It is composed of three primary filaments: microfilaments (7-9 nm) < intermediate filaments (10 nm) < microtubules (25 nm). The various functions carried out along the cytoplasm often require energy from atp or gtp hydrolysis. Microtubules are a repeating structure (polymer) of and tubulin monomers. Together, an and tubulin form an dimer as the basic microtubule subunit. Because they conjugate into a dimer, and tubulin are almost never found separately. Instead they stretch end to end in a dimeric form, creating a protofilament (striated chain of tubulin dimers) that has polarity (one end and one end ). It takes 13 protofilaments to form the hollow tube structure of a microtubule.
