Biology 2581B Chapter Notes - Chapter 6: Proband, Genetic Testing, Blood Proteins
11 Feb 2018
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6. 2 using pedigrees to study inheritance characteristics in humans. Autosomal dominant traits should appear with equal frequency in both sexes & not skip generations. If a trait is only passed from father to son, will never be x-linked. Appear with 50-50 in both sexes unless there"s an unequal penetrance b/w the 2 sexes. Tends to skip generations it is easy for a recessive allele to be passed on for generations without appearing (as long as the mating partner is not another carrier) More likely to appear if progeny of related parents mate. Greater chance of both parents being carriers. Even if both parents of carriers, the 3:1 ratio is not true unless the family size is large (that is just a probability) All o springs are a ected if both parents are affected by the recessive trait. Ex: taysachs disease a ected individuals lack to gene to make an enzyme that breaks down fat in the brain.
