Biochemistry 2280A Chapter 20: Topic 24 - Molecular Basis of Cancer Learning Objectives
23 Aug 2016
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Originate from alteration of cell"s ability to control its growth/differentiation. Defined by 2 heritable properties, they and their progeny: a. i. Proliferate in defiance of the normal constraints a. ii. Invade & colonize territories normally reserved for other cells. Malignant cells invade surrounding tissues (i and ii) and form secondary tumours (metastases) Its mutations are somatic mutations those that occur in individual somatic cells. Cancer cells are genetically unstable, which results from: mutations that interfere with the accurate replication & maintenance of the genome & thereby increase the mutation rate itself. Maybe a defect in protein needed to repair damaged dna/correct errors. Defect in cell-cycle checkpoint mechanisms that would prevent damaged dna from dividing. Fault in mitosis machinery, leading to abnormal chromosomal numbers. Reduced dependence on signals from other cells for survival, growth, and division. Survive levels of stress & internal derangement that would cause normal cells to undergo apoptosis.
