BIOC 300B Chapter Notes - Chapter 29: Rna Splicing, Sidney Altman, Phosphodiester Bond
19 Jan 2018
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Rna splicing: the spicing mrna precursors is catalyzed by splicesomes (protein complexes consisting of snrnps) Some rna molecules can self-splice in the absence of protein thomas cech and. Sidney altman = rna can serve as catalysts. Many genetic diseases are associated with mutations that a ect rna splicing. Mrna can be spliced di erently based on cell type, stages of development, in response to signals. Mrna editing: individual bases in pre-mrna are changed. The ability for one gene = encode more than one distinct mrna by alternative splicing = more than one protein expands our repertoire of the genome. Interact with activator and repressor proteins to modulate transcriptional rates (gene expression is controlled at the level of transcription) Fundamental reaction: formation of the phosphodiester bond. The 3"-hydroxyl group of the last nucleotide in the chain nucleophilically attacks the alpha-phosphoryl group of the incoming nucleoside > releases pyrophosphate.
