BIOC 299 Chapter 5-17: BIOC 299 – Notes 2
15 Mar 2018
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Allosteric enzymes: enzymes that conform to simple michaelis-menten kinetics are called michaelis-menten. Enzymes: these enzymes are not regulated in the cell, and their activity is governed simply by mass action: if substrate is present, they catalyze. Michaelis-menten enzymes: as important as catalysis is to the function of a cell, catalysis alone is not sufficient. Let us begin our consideration of allosteric enzymes by imagining what control processes would be useful for the efficient functioning of metabolic pathways. Heterotropic effectors shift the sigmoidal curve to the left (activators) or right (inhibitors). In contrast, the effects of substrates on allosteric enzymes are referred to as homotropic effects. Homotropic effects account for the sigmoidal nature of the kinetic curves. The results of studies on a number of allosteric proteins suggest that many behave according to some combination of the sequential and concerted models.
