PCL102H1 Chapter Notes - Chapter 12: Null Hypothesis, Vomiting, Chemotherapy
17 Feb 2017
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Independent review: unaffiliated individuals must review the research and approve, amend, or terminate it. Examples that are not socially or scientifically valuable include clinical research with nongeneralizable results, a trifling hypothesis, or substantial or total overlap with proven results. Research with results that could not be practically implemented even if effective is also not valuable. Value should be an ethical requirement for responsible use of finite resources and avoidance of exploitation: resources are limited and human beings should not be exposed to harm without some social or scientific benefit o scientific validity. It must be possible to execute the proposed study. Research that uses biased samples, questions or statistical evaluations, neglects critical end points, or doesn"t enroll sufficient subjects cannot generate valid scientific knowledge and is thus unethical. Research that is conducted in a sloppy/inaccurate manner or produces uninterpretable data is a waste of time and resources, therefore unethical. Clinical research that compares therapies must have an honest null hypothesis.
