HMB200H1 Chapter Notes - Chapter 6: Synaptic Plasticity, Nmda Receptor, Chemical Synapse
Document Summary
Synapic depression and facilitaion, not always found at the same synapse. Some synapses have one but not the other, some have both. Ap in sensory neuron makes epsp in motor neuron 2nd ap in sensor neuron 200msec ater the irst makes epsp that is smaller and produced by irst ap. Synapic depression not constant, varies dependent on simulaion. Funcions on depleion of available transmiter 2nd of 2 aps release less transmiter because less is available to be released. Twin pulse facilitaion: 2 ap"s in presynapic cell produce 2. 1sst is 1mv epsp and second is 20msec ater the irst and. Net is when you add them together. Residual calcium is when ap leads to opening of ca2+ channels and the inlux of ca2+ leads to release of transmiter. Fate of ca2+ ater irst ap will decline back to normal levels but not instantly. If a second ap wants to be ired then it can with the residual.
