BCH210H1 Chapter 29: R29
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BCH210H1 Full Course Notes
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Signal amplification: a single hormone-receptor complex can activate several g proteins, adenylate cyclase can generate many camp secondary messengers, demonstrates how one hormone can activate a product of enzymes every step you get more and more. Start off with one hormone and lead to 10,000 glucose molecules (breadown of glycogen gives glucose molecules) How does ligand binding lead to g activation: structures solved for both inactive and active 2ar, ligand binding induces, very small changes locally (extracellular face) 0. 2 nm of movement: large conformation changes at bottom (inside) 1. 4 nm of movement: the large conformational change promotes gdp release. Objective: understand how and why membrane proteins fold the way they do in the bilayer, show how structure informs function, ex. Bacteriorhodopsin: describe special case of beta sheets in membranes. Recall from lecture 3: amino acids in membrane spanning segments are mostly hydrophobic, problem #1: