BCH210H1 Chapter 16: R16

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

For non competitive inhibition; increasing the [s] will fail to overcome its inhibition (there is no problem with the substrate binding; it is the activity that is affected km is unaffected) Irreversible enzyme inhibition: aspirin"s main target is cox (cyclooxygenase, in an enzymatic reaction an acetyl group is transferred onto a specific serine residue in the channel leading to the active site. Penicillin: ring: has a very reactive peptide bond apart of the b-lactam, it is powerful in terms of covalently modifying glycopeptide transpeptidase. Which is responsible for synthesizing bacterial cell walls. Therefore if someone has a bacterial infection, most likely they will be given a penicillin shot: penicillin will covalently link to a serine residue which is located on the active site. Therefore, inactivating the enzyme: this will cause the bacterial cells to lyse, halting bacterial cell growth. The only way to recover this inhibition is to synthesize more of the glycopeptide transpeptidase.