PSYC62H3 Chapter Notes - Chapter 3: Tryptophan Hydroxylase, Glutamine, Monoamine Neurotransmitter

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Influence on local potentials from other neurons occurs as one of the below: excitatory postsynaptic potential (epsp): stimulus that depolarizes a local potential. If no other epsps occurs depolarization quickly ends, resting potential resumes. G protein-coupled receptors: g protein: a three-subunit protein that carries out effects of a metabotropic receptor, three subunits, alpha ( ) Clara rebello: beta ( , gamma ( , subunits remain attached to each other until a neurotransmitter activates the receptor, activating receptor causes g protein to separate into two sections, su(cid:271)u(cid:374)it, combination (dimer) Ionotropic receptors: nmda (n-methyl-d-aspartate, ampa ( -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid, kainite, metabotropic, mglu, activated receptors allow + charged ions (ca2+ and na+) to enter a neuron. Influx of + charged ions function can cause epsps. Important for effects of cns depressants: gabab: metabotropic, both types produce inhibitory effects when bound by gaba, after gaba neurotransmitters release from receptors, astrocytes terminate neurotransmission by transporting gaba into astrocytes.

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