PSYC62H3 Chapter 7: nicotine SAQ
10 Mar 2017
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A: once absorbed, nicotine passes through the bbb. In the liver, the enzyme cyp-2a6 metabolises 80-90% of nicotine content, producing the active metabolite cotinine (e. g. produces pharmacological actions like nicotine). Genetic polymorphism such as reduce activity of cyp- A: when bound to by an agonist, nicotinic receptors undergo an active state and then a desensitized state. A: during chronic nicotine administration, nicotine acts as a functional antagonist whereby the brain compensates for the closing of nicotinic-receptor channels by upregulating nicotinic receptors. A: they are found in the cerebral cortex, hippocampus, basal ganglia, substantia nigra, vta and. Nicotine release in the vta > nicotine release in nu. Nicotine is responsible for a # of cancers each year, and deaths related to second-hand smoke. Cardiovascular health is severely compromised, and smokers report a feeling of appetite suppression following smoking, which is one of the many reasons nrt focus on treatment that aid in weight loss.
