PSYC62H3 Chapter Notes - Chapter 4: Chemical Substance, Endocrine Disruptor, Endocrine System
31 Jan 2017
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Does not affect how drug effects but does change how quickly drug reaches the brain. *involves how drug administered, absorbed into bloodstream, permeates different body parts, eliminated from body. Treatment useless if drug cannot reach site of action. Pharmacodynamics: how drugs cause biological changes in the body. Pharmacokinetic properties: absorption: entry of a drug into the circulatory system, particular membrane it must past th(cid:396)ough depe(cid:374)ds o(cid:374) d(cid:396)ug"s (cid:396)oute of administration. Intravenous avoids absorption limitations and rapid: can be useful for immediate emerngecy attention, noncompliance; inability or unwanted medication. Elimination also determines how long a drug"s effect will last. Refers to mechanisms of action for a drug. Largely deals with actions of a drug at synapses: altering neurotransmission at the synapse. Dependent on drug"s characteristics; may alter any stage of neurotransmission. Dissociation constant: (kd) or an inhibition constant (ki) Binding affinity: drug"s strength of biding to a receptor.
