NROB60H3 Chapter 4: Chapter 4 Notes

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23 Apr 2011
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Action potential: conveys information over distances in the nervous system. Often called a spike, nerve impulse, or a discharge. Frequency and pattern of action potentials constitute the code used by neurons to transfer information from one location to another. Rising phase: characterized by a rapid depolarization of the membrane; continues to peak until vm reaches 40 mv. Overshoot: phases where inside of the neuron is positively charged with respect to the outside. Falling phase: rapid repolarization until the membrane is actually more negative than the resting potential. Perception of sharp pain when a thumbtack enters your foot is caused by the generation of action potentials in certain nerve fibers in the skin: chain of events: membrane of nerve fibers is stretched (causes activation of specialized ion channels sensitive to membrane stretching) na+ - permeable channels open; depolarizes membrane beyond threshold. Applying increasing depolarization to a neuron has no effect until it crosses threshold; therefore aps are all-or-none.

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