BIOC39H3 Chapter Notes - Chapter 2: Innate Immune System, Serine Protease, Complement Control Protein
10 Feb 2017
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Document Summary
Many commensal bacteria have developed symbiotic relationships with their hosts, which mutually improve their nutrition, metabolism, and general health. Pathogens are a diverse collection of organisms that exploit the human body in numerous ways: extracellular pathogens are accessible to soluble, secreted molecules of the immune system, intracellular pathogens are not. Strategy used to attack intracellular pathogens is to kill the human cells in which the pathogens are living. Exposes any pathogens released to the soluble molecules of the. Each enzyme is highly specific for the complement component it cleaves. Cleavage is usually at a single site. This attachment is the essential function of the complement system. Results in some of the c3b becoming covalently bonded to the pathogen. Most c3b remains in solution in an inactive hydrolyzed form. Also part of innate immunity: the classical pathway of complement activation requires the binding of either antibody or an innate immune-system protein called c-reactive protein to the pathogen"s surface.
