PHA 3112 Chapter Notes - Chapter 86: Corynebacterium Diphtheriae, Side Effects Of Penicillin, Infective Endocarditis
10 Dec 2016
School
Department
Course
Professor
Document Summary
Drug list - chapter 86 bacteriostatic inhibitors of protein synthesis: clindamycin [dalacin, others]: Due to colitis risk, indications are limited . Uses only for certain anaerobic infections located outside the cns promote severe antibiotic-associated pseudomembranous colitis, can be fatal: erythromycin [eryc, erysol] Macrolides: broad-spectrum antibiotics that inhibit bacterial protein synthesis. All of newer macrolides are derivatives of erythromycin: Antibacterial effects caused by protein synthesis inhibition similar as tetracycline. Acquired resistance: bacteria can become resistant by two mechanisms: production of a pump that exports drug & 2) modification of target ribosomes so erythromycin binding is impaired. Antimicrobial spectrum: drug is active against most gram-positive bacteria & gram-negative bacteria. Erythromycin has similar antibacterial spectrum to penicillin. First choice treatment for several infections & may be used as an alternative to penicillin g in pts w/ penicillin allergy. 7) preventing recurrences of rheumatic fever & bacterial endocarditis. Qt interval = pose risk for potentially fatal ventricular dysrhythmias = sudden death can result.
