HSS 3106 Chapter Notes - Chapter 2 & 3: Lipophilicity, Drug Metabolism, Enteric Coating

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 3106
• Professor: Ron Saulnier

Document Summary

Pharmacokinetics: movement of a drug from consumption (entry) to elimination (removal: movement of drugs across plasma membranes; what the body does with the drug, assist hc professionals in understanding the mechanism of action and adverse effects of drugs. Routes of administration determined by properties of drug and the therapeutic objective. Iv avoid first pass effects, allow most control over circulating level of agent. Invasive; once given, iv drugs are difficult to remove (emesis, charcoal) Drugs need to cross pm via diffusion (passive transport) or active transport. < 100% bioavailability: some portion of the drug is destroyed in gut, not absorbed, destroyed by gut wall, destroyed by liver. Lipid-soluble drugs and weak acids may be absorbed directly from the stomach; weak bases are not normally absorbed from the site. Other routes lungs, breast milk, sweat/tears, urine/feces, bile (feces), saliva. Frequency distribution curve number of patients that respond to a drug"s action at different doses.