HSS 2305 Chapter 5: 04. Molecular Mechanism of Disease Textbook Note Chapter 5
3 Dec 2016
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Oxygen appeared in atmosphere about 2. 5 billion yrs ago species relying on molecular oxygen and using oxygen to produce energy-aerobes. Mitochondria specialized organelle that utilize oxygen to generate cellular energy. Mitochondrial fission: split in 2; induced by endoplasmic reticulum(er) (not always) The balance between the two is a major determinant of mitochondrial #, length, and a degree of interconnection. Mitochondrial membranes: the outer and inner membranes are ~50% and 75% protein. The outer mitochondrial membrane: completely encloses the mitochondria, serve as its outer boundary. Contains a large pore forming protein called porin: large pore-forming protein-permeable. The inner mitochondrial membrane: subdivided into 2 major domains that have different protein residents and carry out distinct functions. The inner boundary membrane covers inside the outer mitochondrial membrane, forming a double-membrane outer envelope rich in the proteins responsible for the import of mitochondrial proteins. Other domain lies in the organelle in cristae: a series of wrinkled membranous sheets.
