PCTH 201 Chapter Notes - Chapter 19: Hydrophile, Aminoglycoside, Quinolone
22 Nov 2017
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Document Summary
Various strains of bacteria have changed in resistance (leads to new drug development) Hospital acquired: get after being at the hospital or visiting someone at the hospital. After a newly developed antibiotic is introduced in clinical practice, antibiotic resistance will develop in time. The most threatening form of resistance is mrsa, vancomycin, fluoroquinolone. Decreasing number in antibiotics being developed fewer drug companies investing time to research new antibiotics. Increased rates of treatment failure = diminished treatment success. We might use two drugs to treat the bacterial disease, but. Exposing a strain of antibiotic-sensitive bacteria to new antibiotic increase the chance of it to gain resistance i. e. leading to multidrug resistance (mdr) strains. Helping in the short term, but perpetuating the long term problem. Mechanism of antibiotic resistance: evolution or genetics, environmental factors. A mutation in the target of the antibiotic. Changes in receptor expression (protein or enzyme) Use of different enzyme to do same job (altering target)
