PCTH 201 Chapter Notes - Chapter 15: Gastroparesis, Reactive Oxygen Species, Delirium Tremens
5 Nov 2017
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When yeast keeps producing alcohol, it kills itself from alcohol toxicity a byproduct of . Came from natural process of malting/fermentation of grapes. Have ability to work in most region of the body. General membrane fluidity (increase circumference of the cell) disrupting key interactions of cellular proteins. Progressing up scale in parallel with ethanol intake/concentration. Increase [blood alcohol] in cerebellum: motor skilled inhibited. Increase [alcohol] in brain stem: dangerous, damage functions that keep you alive. Prevent antidiuresis: don"t have to drink as much to keep your body hydrated. Wine/spirits (heavy alcohols): losing fluid for each amount of alcohol you take in. Similar ratio as in humans for drinkers and nondrinkers. Liking for alcohols is mainly determined by our genes. Significantly upregulated of cyp450 enzymes: primary (major pathway) Of drug metabolized is constant not fraction. Aldh2 single amino acid change loses 90% of enzyme activity. More prevalent in asian population (shown in studies)
