PCTH 201 Chapter Notes - Chapter 14: Septic Shock, Adrenergic Receptor, Antihypotensive Agent

• School: UBC
• Department: Pharmacology and Therapeutics
• Course: PCTH 201
• Professor: Andrew Horne

Document Summary

All our cells are diploid: 46 chromosomes, 23 pairs of chromosomes. Snips: you can have one nucleotide polymorphism, only one single nucleotide that is different, they can be part of the exon or intron. If on exon: it could affect the protein structure. If o(cid:374) i(cid:374)tro(cid:374): (cid:449)o(cid:374)"t really ha(cid:448)e huge effe(cid:272)t si(cid:374)(cid:272)e it is spli(cid:272)ed out, (cid:373)ay affe(cid:272)t (cid:271)i(cid:374)di(cid:374)g o(cid:374) transcription factors. If it does(cid:374)"t (cid:272)ha(cid:374)ge your protei(cid:374) stru(cid:272)ture, does(cid:374)"t (cid:373)ea(cid:374) it"s (cid:374)ot i(cid:373)porta(cid:374)t ((cid:373)ay (cid:272)ha(cid:374)ge protein stability, binding affinity: most of the snips are in introns (junk dna) Snips are part of the septic shock and step to sepsis. Septic shock hypotension, organ damage especially in kidney (very much related to blood pressure) Lost of circulation in legs and fingers, complete coagulation and inhibition of blood flow. Starts with a severe bacterial infection and are given ab treatments. Consequences: massive vasodilation (negative effect on kidney, blood flow issues, heart will start to fail, kidney failure.