MICR 3230 Chapter Notes - Chapter 4: Etanercept, Fadd, Adalimumab
14 Mar 2016
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Document Summary
Mediate efector funcions of immune system by binding rc"s on another cell. Act in 3 ways: endocrine (via blood), paracrine (short distances), autocrine (same cell) Numerous biological funcions: change difereniaion, proliferaion, or induce death in target cells, by changing enzyme acivity and gene expression. Il-1, il-6, tnf fever, loss of appeite, sore muscles. Secreted by innate cells (il-1, tnf , cxcl8) & adapive cells (il-2, il-4, il-17) Disinguished by structure of ligand and receptor & nature of signaling pathway induced: il-1 family. Simulated by viral, parasiic, or bacterial ag"s to promote inlammaion. Secreted very early in immune response by dc"s and macrophages. Locally: increase capillary permeability to draw leukocytes to infected issues. Systemically: signal liver to produce acute phase proteins. Il-18 uses same rc family and signaling pathway as il-1 (inhibiion: il18bp binds. Il18 to prevent it from binding receptor: hematopoiten (class 1) family. Misleading name: not all have blood-clot forming funcion. May signal difereniaion, acivaion, ab secreion, etc.
