PSYC 375 Chapter Notes - Chapter 5: Choline Acetyltransferase, Oliver Sacks, Axon Terminal
15 Jul 2016
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Type i synapse: excitatory, shafts/spines of dendrites, round vesicles, wider cleft and larger active zone. Type ii synapse: inhibitory, cell body, attened vesicles. Evolution from digestive processes of single-celled animals exocytosis ~ vesicles and release of neurotransmitter for communication. Cns thousands of synapses packed around every neuron, preventing easy access to a single synapse and its activities putative transmitter suspect chemical that has not yet met all criteria of neurotransmitter. Techniques to identify substances that may be cns neurotransmitters: 3. stimulation glass micro electrode lled with chemical of interest, current through electrode, chemical ejected into/onto neuron to mimic release of neurotransmitter onto cell staining collecting. Acetylcholine rst substance identi ed as neurotransmitter and as cns nt used by all motor-neurons sons leaving spinal cord. Ne excitatory transmitter at mammalian heart supply of tyrosine hydroxyls is limited > limits rate of da, ep, ne.
