MICR 221 Chapter Notes - Chapter 39.1a Clamidyial pneumonia and Diphteria: Inclusion Bodies, Phagocytosis, Gram-Negative Bacteria
8 Mar 2020
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Must grow and reproduce within host cells. Many species grown in animals and plants without any adverse effects. Minimal metabolic activitiy; cannot synthesize their own proteins. Host cells phagocytose ebs they are held in inclusion bodies they reorganize to form rbs. After 8-10 hr after infection rbs undergo binary fission. Reproduction occurs until the host cell dies. Rbs differentiate into infectious ebs (48-72 hrs after infection) Fun fact: chlamydia-filled inclusion body - large enough that visible by light microscopy. C. pneumonia likely a human pathogen transmitted among humans by droplet (respiratory secretions) So adapted to airborne transmission via nasopharyngeal secretions. The bacteria that carry a prophage containing the tox gene produce diphtheria toxin. Therefore, the tox phage infection of c. diphtheriae required for toxin production. Causes formation of a greyish pseudomembrane in pharynx + respiratory mucosa. Pseudomembrane: consists of dead host cells and cells of c. diphtheriae. Is absorbed into the circulatory system, distributed throughout the body.
