MEDRADSC 2T03 Chapter Notes - Chapter 2: N-Myc, Image Sensor, Machinist
27 Jun 2016
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Document Summary
Retinoblastoma (rb) is a rare malignant tumour that starts in the cells of the retina in the eye. It is the most common type of eye cancer in children. Incidence: accounts for 3% of cancers occurring in children younger than 15 years. 4 cases per 1 million children <15yrs annually in the us. 2/3 of cases are diagnosed before 2yrs old; 95% of cases are diagnosed before 5yrs old. 60% of cases are sporadic non-hereditary and occur in 1 eye. 30% of cases are sporadic-hereditary, occurring in both eyes. 10% of cases have a familial link (familial retinoblastoma) wand will occur in both eyes. Environmental: father"s occupation (eg. military, metal industry, welder, machinist), prenatal exposure to x-ray, prenatal exposure to medical radiation of reproductive organs, in vitro fertilization, mothers who smoked. Biological: family history of retinoblastoma, having older parents. Genetic: a result of a rb1 gene mutation which causes retinoblast cells to replicate out of control.
