HTHSCI 2H03 Chapter Notes - Chapter Module 2: Amenorrhoea, Alendronic Acid, Caffeine
10 Oct 2017
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Document Summary
Osteoporosis: systemic skeletal disorder characterized by bone mass density (bmd) leading to: diminished stature, bone fragility, bone mass density declines after age 35. Affects: women, 1/8 men, caucasian women have a remaining lifetime risk of 40% for hip, vertebra, or wrist fractures. Calcium- bone of the most important and abundant materials in the body: 99% is localized in the teeth and bones, other 1% is in extracellular fluid and soft tissue. Deposition: calcium derived from diet moves from intestines to bone. Reservoir for calcium and phosphate, magnesium and carbonate. Reabsorption: unbound, ionized calcium (ca+) moves from bone into bloodstream when serum calcium levels are low. A small amount of calcium exists in an unbound ionized form that moves from bone into the bloodstream when serum calcium is low. Bone deposition and reabsorption: calcium deficiency caused by, poor diet, hormonal alterations, hypersecretion of pth, hyposecretion of calcitonin, medications. Corticosteroids: calcium moves from bone to bloodstream to compensate.
