HTHSCI 2H03 Chapter Notes - Chapter 1: Takers, Reaction Rate Constant, Ketorolac
16 Sep 2017
School
Department
Course
Professor
Document Summary
Explain application of pharmacokinetics to a clinical setting. Identify drugs as weak acids or bases. Use the henderson-hasselbalch equation to determine sites of drug absorptions. Define terms: half life, apparent volume of distribution, and clearance. Henderson hasselbach equation ph = pka + log ([a-]/[ha]) Describes how the ph of a solution affects the concentration of ionized and nonionized substances in that solution. Shows where in the body an acidic drug will be absorbed after consumption. Pharmaceutical drugs are either very weak bases or very weak acids. Acids- the givers : dissociate in water to produce or give a hydrogen cation (proton) Bases- the takers : accept or take hydrogen cations (protons) in water. Only drugs in their non-ionized neutral form can pass through plasma membranes. Plasma membrane- double lipid bilayer have very long fatty acid chains, making the entire membrane relatively nonpolar. Only fat soluble compounds (non polar) can pass through this membranes.
