BIOCHEM 2B03 Chapter Notes - Chapter 1: Solenoid, Pyrimidine, Uracil
27 Nov 2015
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Prime" indicates numbering on carbon, and not on the nitrogen base. Phosphoric acid is esterified to a sugar"s oh group of a nucleoside o. 2" deoxyribose has 2 oh that can be esterified: c 2", c 3" and c 5": ribose has 3 oh available: c 3" and c 5" (nucleoside. Cyclic nucleotides: signal molecules (camp and cgmp) If dna had u instead of t, the proofreading mechanism could not readily distinguish u formed by c deanimation vs. a u correctly paired with a. Carries the info in genes to sites of protein synthesis to make polypeptide sequence. 1 mrna = 1 polypeptide chain that"s more complex. Helix stabilized: h bonds, base stacking interactions and electrostatic repulsion of phosphate groups (makes them more stable on the helix exterior) Ethidium bromide: dna visualization o: cancer drugs that stop transcription of tumor cells during replication. The screening of other distamycin derivatives, which maintain antitumor activity and exhibit much lower toxicity against human.
