BIOCHEM 2B03 Chapter Notes - Chapter 5: Genetic Code, Transferase, Ribosome
27 Nov 2015
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Codon is recognized by a specific aminoacyl trna (aars) through base pairing via anticodon loop. Code that aars matches up its aa with trna constitutes a second genetic code o trna"s anticodon will match up with the mrna aars discriminate various trnas and aas o. Classes of aars: first add aa to 2" oh of terminal adenylate residue of trna before shifting to 3"oh, add it directly to the 3" oh aars reaction. Numbers are standardized numbering of. Dots : nucleotides vary between trna places where number of trna recognition. For most trnas, a set of sequence elements is recognized by its specific aars, rather than a single distinctive nucleotide or base pair. Right: major identifying elements in four trna species. Filled circles indicate positions of identity elements within the trna that are recognized by its specific aars. Mutations alters sense codon nonsense codons: uaa, uag, uga: result: premature termination of protein synthesis and release of truncated (incomplete) proteins.
