PSYC 311 Chapter Notes - Chapter 16.9: Frontal Lobe, Attention Deficit Hyperactivity Disorder, Nucleus Accumbens
9 Jun 2016
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Several studies have accumulated evidence that implicates the serotonin transporter in depression. Moreover, the increase was much greater for people with one or two copies of the short allele for the 5-htt promoter: this is evidence of an interaction between environments and genetics. Many other studies suggest that the 5-htt promoter plays an important role in the development of depression: e. g. It has been found that patients with two long alleles for the gene were more likely to respond to treatment via an antidepressant drug and even when administered a placebo: e. g. Depressed people with two long alleles who were treated with antidepressant drugs had a much better long-term outcome: e. g. Tryptophan depletion is most likely to produce depression in individuals with two short alleles. Unfortunately meta-analyses have yielded no significant effect for the 5-htt promoter. It has been suggested that the frontal cortex plays a critical role in development of depression.
