NEUR 1201 Chapter Notes - Chapter 2: Morphogenesis, Neural Tube, Ommatidium
22 Feb 2018
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The eye of the fly develops from a uniform looking disc of cells into tightly packed hexagons. In late larval stages, optic disk marked by a morphogenetic furrow: starts at posterior and moves anteriorly, behind furrow, cells differentiate. The ge(cid:374)e hedgehog p(cid:396)odu(cid:272)es a se(cid:272)(cid:396)eted p(cid:396)otei(cid:374) that"s (cid:396)e(cid:395)ui(cid:396)ed to fo(cid:396)(cid:373) fu(cid:396)(cid:396)o(cid:449) Induces cells to stop dividing and start differentiating, and then to start secreting hh as well, acting as a morphogenetic wave. Hh induces expression of decapentaplegic which induces cells to express proneural genes. R8 is the first to express neuron specific genes (in the center: directs fate of other receptors by regulating gene expression in r2 and r5. R2 and r5 differentiate on either side: team up with r8 to induce differentiation in other receptors. R7 detects uv light which will cause it to mature last: controlled exclusively by r8, gene called bride of sevenless is crucial for differentiation (r8 expresses this gene to activate r7)
