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BSCI-1510 Study Guide - Midterm Guide: Allosteric Regulation, Pyruvic Acid, Adenine

195 views11 pages
pucehound879
17 Oct 2016
School
Vanderbilt University
Department
Biological Sciences
Course
BSCI-1510
Professor
Singleton Charles

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Document Summary

Alpha tubulin binds gtp while beta tubulin binds and hydrolyzes gtp to make. Beta tubulin is a gtpase and can convert gtp to gdp and vice versa. G-proteins (like beta tubulin) are like on/off switches. Beta form w gtp is involved in growth and the beta form with gdp is. Involved in the assembly and disassembly of microtubules involved in disassembly. Singlet = 13 dimers; doublet = 13,10; triplet = 13,10,10. Doublets and triplets are found in more specialized structures; they are more stable and last longer. Centrosome = 2 centrioles and pericentriolic matrix. Centrioles are triplet microtubules interconnected with other proteins. Centrosomes are stable (last forever) and are typically found in the middle of the cell. Most mts radiate out from the centrosome. There are nucleating centers in the pericentriolic matrix. Microtubules are built one alpha-beta protofilament at a time. Mts have structural polarity: (-) at the gamma/alpha end and (+) at the beta (growing) end.

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Related Questions

7 questions could use some help on for Molecular Biology. Pleasehelp. Just answers will do (I'll figure out), but wouldn't mindexplanations. If answered correctly 5 star guarantee & goodattempt definite 'best answer'. Thanks!

Question1

Which of the following cytoskeletal components is thelargest?

  1. Microtubules

  2. Microfilaments (actin)

  3. Intermediate filaments

Question2

During mitosis, all microtubules emanate from the centrosome.Therefore, the centrosome is an example of:

  1. a microtubule organizing center (MTOC)

  2. A +TIP protein

  3. A catastrophin

  4. A monomer sequestering protein

Question3

Tubulin is a G-protein. It can stabilize microtubules when boundto which of the following?

  1. GDP

  2. GTP

  3. Either GTP or GDP

  4. Neither GTP nor GDP

Question4

In the formation of microtubules, dimers are built when analpha-tubulin protein binds to a beta-tubulin protein. This is anexample of what level of protein structure?

  1. Primary structure

  2. Secondary structure

  3. Tertiary structure

  4. Quartenary structure

Question5

Different tissues in the body express slightly differentversions of alpha tubulin. Which of the following could lead toslightly different alpha-tubulin molecules with a modified proteinsequence?

  1. One tissue has more DNA methylation upstream of thealpha-tubulin gene.

  2. One tissue has more miRNAs produced than the other.

  3. One tissue uses different splice sites than the other.

  4. One tissue has different trans-elements than the other.

Question6

  1. How is confocal microscopy different from traditionalfluorescent microscopy?

  2. The molecules are labelled red instead of green.

  3. The molecules are observed over time.

  4. The molecules are observed in many thin planes, which are thenstacked together to create a crisper image.

  5. The confocal microscope has higher objective power than regularfluorescent microscopes.

Question7

Taxol is a chemotherapy drug that permanently stabilizesmicrotubules and prevents their degradation. Describe howmicrotubules are typically destroyed and why permanentstabilization would kill dividing cells. Note: you may need toreview the basics of cell mitosis from a previous course.