ONCOLOGY 401 Study Guide - Final Guide: Tyrosine Kinase, Platelet-Derived Growth Factor, Wound Healing
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Lecture 11: receptors part 1: wound healing assay, experiment: take two separate dishes, 1) normal fibroblasts and 2) Lecture 13: intracellular signaling part 1: ras and examples of ras mutations in cancers, a g-protein, is mutated (gain of function) in 20-30% of all human cancers, discovered as a viral oncogene in harvy sarcoma virus and kristen. E545k, and h1047r- make pi3k active (doesn"t need to be bound to. Lecture 15: eternal life: immortalization, a process whereby a cell population normally having limited replicative potential acquires the ability to multiply indefinitely. ** telomerase activity is good because it is necessary for overall well being. Mice lacking telomerase activity age prematurely because presumably telomere shortening triggers crisis in too many cells. Cancers with telomerase activity escape crisis, so tumors can progress and metastasize because the cancer cells do not die. This list may not include all things covered on the exam, but is intended to be a guide.