NURS 165 Study Guide - Final Guide: Loop Diuretic, Dysgeusia, Angioedema
Heart Failure
Drug
Indication
Mechanism
Onset
t1/2
Excretion
Adverse Effects
Caution
Interactions
Furosemide
volume
overload,
edema
Loop diuretic
IV: .5-1h
PO: 5min
IV:6-8h
PO: 2h
renal,
some
hepatic
volume depletion,
hypotension,
hypomagnesemia,
hypocalcemia,
hyperglycemia, ototoxicity
pregnancy
antihypertensives, Digoxin,
NSAIDs, lithium,
aminoglycoside antibiotics
Spironolact
one
HTN,
edema
K-sparing diuretic
24-48h
48-72h
renal
hyperkalemia, endocrine
effects
other diuretics, ACE-
inibitors, K supplements
Lisinopril
HTN, HF,
MI,
nephropat
hy
ACEI: reduces angiotesin
II, elevates bradykinin
NOT a
prodrug
renal
hypotension, hyperkalemia,
cough, angioedema,
dysgeusia, rash
DONT USE:
pregnancy,
bilateral
renal
stenosis
diuretics or other
antihypertensives, K
supplements
Losartan
HTN, HF,
nephropat
hy
ARBs/ AIIAs: blocks
type1 angiotensin II
receptor
renal
hypotension, hyperkalemia,
angioedema, dysgeusia, rash
DONT USE:
pregnancy,
bilateral
renal
setenosis
diuretics or other
antihypertensives, K
supplements
Carvedilol
HF, HTN
beta and alpha1 blocker:
decrease HR, AV
conduction, contractility
hepatic
metb,
renal
bradycardia, dizziness,
worsening HF
Digoxin
HF, atrial
fibrillation
inhibits Na-K-ATPase
pump, increases
intracellular Ca
Reqs.
monito
ring
renal
bradycardia, NV, fatigue,
visual disturbances
hypokalem
ia
diuretics, BB, CCB,
quinidine, cholestyramine
Dobutamine
HF
beta1 agonist
(in
hospital
IV admin)
tachycardia
MAOI, tricyclic
antidepressants, general
anesthetics
Dopamine
HF,
hypoperfu
sion, acute
renal
failure
dopamine and beta 1
agonist, at high doses
alpha1 agonist
(in
hospital
IV admin)
tachycardia, arrhythmia,
angina, tissue necrosis
MAOI, tricyclic
antidepressants, general
anesthetics, diuretics
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