CHEM 451 Study Guide - Final Guide: Groes, Atp Hydrolysis, Groel
Document Summary
Interring stabilisation in shsp (lecture 16 slide 2) Shsp assemble into oligomeric structure that have a variety of different types of assemblies. Thought that disassembly of structures -> functional subunit (dimer) Regulated by modifications in n terminal region for assembly of oligomeric subunits to functional dimeric subunit. N terminus causes dissociation, for hsp16. 9 c terminus makes interaction within ring between. C and n terminal regions differences give differences in dimer assemblies. C and n terminus are specific to hsp16. 9. Hsp16. 9 are 2 x 6 rings stacked ontop of each other. Phosphorylation leads to dissassemble/ won"t make favourable interactions. Know basic topology of hwat makes up subunit. Hydrophobic binding sites and flexibility around hinge - these conf changes sequesters hydrophobic residues that is importnat for substrate binding and contacts with groes. Flexibility in hinge region is where nucleotide binding site, which is close to terminus of helix d.
