NURSE-3111 Study Guide - Midterm Guide: Qt Interval, Coronary Vasospasm, Defibrillation
Document Summary
Mechanism of action: blockade of sodium and chloride reabsorption. Creates osmotic pressure within the nephron that prevents the passive reabsorption of water. As a result, these agents produce the greatest diuresis. To lower intraocular pressure (iop) and not to increase urine production. Mechanism of action: acts in the thick segment of the ascending limb of henle"s loop to block reabsorption of sodium and chloride, by blocking solute reabsorption, furosemide prevents passive reabsorption of water, 20% of nacl is normally reabsorbed in the loop of henle, interference causes profound diuresis: activation of renal prostaglandins- dilation of renal (and other) vessels, reduction in preload/central venous pressure. Hepatic, cardiac, or renal origin that has been unresponsive to less efficacious diuretics. Dilation of the renal blood vessels: hypertension. Reduction in preload also some arteriolar dilation: rapid onset and potent diuresis. Should be avoided when less efficacious diuretics (thiazides) will suffice.
