MICROBIO 310 Study Guide - Quiz Guide: Medline, Antimicrobial Resistance, Evolutionarily Stable Strategy
30 Jun 2016
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Citation: baym m, stone l, kishony r. multidrug evolutionary strategies to reverse antibiotic resistance. News: the significant application of antibiotics in medicine is paradoxical: antibiotics do not just prevent infection but also select for the emergence of a particular strain of resistance that can weaken their effectiveness. In this review, the authors present most recent discoveries that were able to restrict both the advantages and evolution of antibiotic resistance. One of the ways to maintain drug efficacy without risking resistance is to employ the specific synergy between drugs. When combining certain drugs together, one drug can suppress another; thus, becoming resistant to the first drug would automatically make bacteria the ideal target for the second one, which could inhibit them more strongly. Also, based on the dosage and concentration control, we can trigger a synergy between the drugs using the bacterial mutation itself as an inducer.
