MCDB 310 Study Guide - Midterm Guide: Van Der Waals Radius, Covalent Bond, Asymmetric Carbon
20 Feb 2018
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Chapter 1: the human body is made up of c (60%), n (11%), o (9%) and h (6%, bulk elements: na, k, cl, s, ca, p, trace elements: fe, co, cu, zn. It has a bent geometry- tetrahedron with protons on two corners and unshared electrons on the other two corners. Hydrogen bond: highly directional intermolecular association between oxygen of one water molecule and hydrogen of another water molecule, can also form between other electronegative proton donors and acceptors (n, o, In ice, each water molecule makes h-bonds with 4 other water molecules: the open structure causes water to expand and be less dense. Ionic interactions (attraction and repulsion: hydrogen bonds- between peptide bonds, hydrophobic interactions, van der waals interactions. Cumulative effect of weak interactions: crucial for structure of macromolecules, molecular recognition, enzyme-substrate interactions are stabilized by hydrogen-bonding and hydrophobic interactions. Water and proteins: water bound to proteins is essential for their function.
