[BIOLCHEM 415] - Midterm Exam Guide - Comprehensive Notes for the exam (27 pages long!)

• School: U of M
• Department: Biological Chemistry
• Course: BIOLCHEM 415
• Professor: Alex Ninfa

Document Summary

Hba is normal hemoglobin and hbs (deoxygenated form) causes sickle cell disease. Amino acids contain an amino group and a carboxyl group bonded to the same alpha carbon. Gaba (gamma aminobutyric acid) has amino group on the gamma carbon. Glycine is the only achiral amino acid. Aromatic: tryptophan (trp, w) (largest of these; double ring system with n atom, phenylalanine (phe, f) (smallest of these; benzyl ring plus ch2, tyrosine (tyr, y) (oh + phenylalanine; relatively polar) Negatively charged (acidic: aspartic acid (aspartate) [asp, d] is related to asparagine (oh instead of nh2 attached to c=o, glutamic acid (glutamate) [glu, e] is related to glutamine (carboxylate group instead of amide) It"s pka is a(cid:271)out (cid:1010) a(cid:374)d o(cid:374)e n is proto(cid:374)ated (cid:449)hile other is(cid:374)"t at physiological ph and under more acidic conditions, both can become protonated. Catalytic triad in chymotrypsin uses histidine side chai(cid:374)"s a(cid:271)ilit(cid:455) to gai(cid:374) proton and histidine residue in active site removes proton from the.