CHEM 153A Study Guide - Final Guide: Pyruvic Acid, Acetyl-Coa, Insulin
16 Jun 2016
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Product inhibition (competitive for e2 and e3) Pdh phosphatase: activation: parts of the pdh complex. Regulation of phosphorylation of pdh (on e1) (pyruvate -> acetyl-coa) Activate pdh phosphatase (to remove the phosphate group and activate pdh) Adp as inhibitor (reflect need for catabolism/ degradation (more adp = less atp -> need to regenerate atp = reactivating. Atp activator of pdh kinase (need for less atp regenerating in anabolic reaction / more atp utilizing) If have plenty of atp/a lot of product/ lack of reactants. Pyruvate inhibitor of kinase (i. e. activate pdh) *activation physical binding to enzyme to increase the rate (non-covalent interaction/ allosteric activation) Increase ror may not always due to activation. It may be due to the removal of inhibitors (in case of high reactants) In the case of low product, we don"t get inhibition = higher reaction rate. Increase [ca2+] in muscle cells trigger muscle contraction (atp utilizing condition)
