CHEM 153A Study Guide - Final Guide: Lipoamide, Coenzyme A, Lysine
15 Jun 2016
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Involve a transfer of s-s bond in the enzyme. To oxidize the lipoamide/ lipoyllysine (lipoic acid attached to lysine in e2) (the prosthetic group of e2 covalently attach to e2 to. Shuttle from e1 last 2cs of pyruvate, end up in coa-sh in e2. *chaperones do not determine the final protein structure. Only provide space to enhance proper protein folding. If inhibit e2, then no product for e3. But substrate in e2 comes from the product in e1 somewhat. If block at the beginning, then nothing comes after (inhibit. Reoxidize cysteine = transferring hydride ion to nad+ within e3 bound by fad the prosthetic group. 2e going to make fadh2 to nad+ (actually only hydride is transfer to produce. The reaction is thermodynamically unfavorable lipoamide arm facilitates the intermediate channeling from 1 active site to the other between e1,e2,e3. **note the role of cofactor in each individual enzyme. Fad: transfer e from s-s bond to nad+
