CHEM 153A Study Guide - Final Guide: Citric Acid Cycle, Citric Acid, Phosphofructokinase

• School: UCLA
• Department: Chemistry and Biochemistry
• Course: CHEM 153A
• Professor: Tienson

Document Summary

Based on actual physiological concentrations (in the cellular. So changing [sub] does not change km much. But change in [oxaloacetate] leads to relatively larger acticity. Of citrate synthase because the physiological concentration is. Closer to that of the actual km (as it is closer to the. Physiological km on the curve/ on the steep slope?) Regulated whether we can run the pathway: substrate availability (oxaloacetate because of its physiological concentration/ fairly close to the km of citrate / steeper part on the curve. So a small change in the [oxaloacetate] leads to larger change in velocity) Pdh is not part of the tca cycle => its activity does not affect the rate of tca cycle. At that point: can only go up from there. Any change in the [ac-coa] = smaller magnitude change in the initial velocity. So on the curve, land on the steeper slope. A small change in [oaa] = relatively larger change in vo.