CHEM 153A Study Guide - Final Guide: Ionic Bonding, Tautomer, Nucleophile
14 Jun 2016
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Understand how enzymes work at the molecular level. Determine the effect of mutations (ultimately) require total structure determination, but can learn through biochemical analysis. Consider all steps going on in the picture! If a pure solution of compounds, and if the charges are already stabilized under physiological conditions = no need for catalysis. E use an ionic bond to increase proximity and orientation effects/ coordinate positioning of substrates if charges on substrates are full/ stable. If aa are deprotonated for electrostatic catalysis, they stabilize the negative charge of en atoms in the substrate/ on the enzyme. If there is nothing going on = no need to indicate! [a] = 1 molecule/ volume at active site small volume => large local [] and cause proper alignment for reaction. Preferential binding to ts, stabilize ts => decrease. *reaction group face each other in the most favorable alignment for the reaction to occur.
