CHEM 153A Study Guide - Quiz Guide: Oxidoreductase, Isomerase, Lyase
9 Jan 2019
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Enzymes, and catalytic mechanisms: identify 4 features of proteins that make them ideal biological catalysts. Succinyl-coa synthetase or succinate:coenzymea ligase: given the systematic name below, describe the reaction catalyzed by the enzyme, glutamine synthetase. Glutamine is formed (from two molecules) along with the cleavage of atp: glutamine hydrolase. Glutamine is cleaved into two molecules with the addition of water: benzylsuccinate synthase. Or: benzylsuccinate is cleaved to form two molecules, one containing a new double bond: 3-phosphoglycerate mutase changing the molecular formula, glucose kinase. Glucose is phosphorylated with a phosphate from atp. Benzylsuccinate is formed from two molecules by adding one across a double bond in the other. The rate of the reaction is determined by the g between the reactants and the transition state (activation energy). Explain, how this mechanism works: enzymes preferentially bind the transition state (or bind the transition state better than substrate or product), which stabilizes the transition state.
