MCB 4207 Study Guide - Comprehensive Final Exam Guide - Bacteria, Pathogen, Antibiotics
Document Summary
Innate immunity: no memory, first response, happens at surface, epithelial surface, normal flora, biochemical defenses, more complicated/specific, pattern recognition receptors, phagocytosis. Epithelial surfaces have different types and arrangements of cell which work as a barrier for bacteria (challenge for bacteria to pass through). Mucosal epithelial make it harder for bacteria to get through: tight junction between cells help keep bacteria outside. Antimicrobial peptides: cationic particles that destroy bacteria (biochemical defenses). Skin is very effective barrier; breach is usually through a cut or scratch, or through hair follicle. A(cid:374)d : acidic ph, defensins: antimicrobial peptides. Typical response: release of inflammatory cytokines (induce inflammation). Tlr 3, 7/8, 9, 10 are endosomal (inside cell) and mostly bound dna and. Population is becoming more susceptible to pathogen infection. Only 4 companies dealing with antibiotic production. Nosocomial: hospital acquired infections; are becoming a problem. Postsurgical/wound infections: soldiers, for example, encounter these frequently. Normal human microbiota: bacteria produce certain enzymes that aid us in digesting/degrading food.
