BCH 100 Final: Learning Objectives 8: Bioenergetics (Explained)

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Lecture 8: bioenergetics: explain the concept of free energy coupling and additivity of free energy changes. Explain the relationship of the ter(cid:373) (cid:862)high e(cid:374)ergy (cid:271)o(cid:374)d(cid:863) to the (cid:894)(cid:374)egati(cid:448)e(cid:895) free e(cid:374)ergy of hydrolysis of that (cid:271)o(cid:374)d. Overall reactions must be exergonic (- g(cid:895) to o(cid:272)(cid:272)ur. I(cid:374) the (cid:272)ase that a rea(cid:272)tio(cid:374) is e(cid:374)dorgo(cid:374)i(cid:272) (cid:894)+ g(cid:895) the(cid:374) it can be coupled with another reactin that is highler exergonice, like the hydrolysis of atp. Cosider these two reactions and their coupling: The g (cid:448)alues are additi(cid:448)e to total a(cid:374) o(cid:448)erall negative value, rending the complete reaction favorable. A (cid:862)high e(cid:374)ergy(cid:863) (cid:271)o(cid:374)d refers to highly unstable bonds. Draw a conclusion about in which direction it would be favorable to transfer the phosphate (from compound 1 to compound 2, or from compound 2 to compound 1). A transfer of phosphate from atp to glycerol 3-phosphate would be favorable because atp has a high. The -sh (thiol) is deprotonated which allows for coa to be attached.

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