BIS 2A Midterm: Key practice midterm 3

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amethysteel274

21 Dec 2018

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People that lack the wild- type allele for this gene have a blood clotting disorder. The frequency of males born with this clotting disorder is about 1/5000 worldwide. Cats heterozygous for this allele (x xo cats) have patches of orange mixed with patches of black. They"re called tortoise shell cats. An orange male is crossed to a tortoise shell female. Enhancers are frequently found in eukaryotic genes, but not in prokaryotic genes. Dna is often inherited via vertical, as well as horizontal, transmission in eukaryotes. Dna is often inherited via horizontal, as well as vertical, transmission in prokaryotes. Meiotic recombination breaks up gene clusters in eukaryotes, but not prokaryotes. Meiotic recombination breaks up gene clusters in prokaryotes, but not eukaryotes. A mutant is isolated with a nonsense mutation in the 5" end of the gene encoding the trp. A mutant is isolated with a mutation in the trp repressor protein that prevents binding of.

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Part B

Think about the DNA coding sequence of a gene. If an A were swapped for a T, what kind of mutation could it cause and why?

a) It could cause a frameshift nonsense or frameshift missense mutation because it would change the reading frame of the codon triplet.

b) It could cause a silent, missense, or nonsense mutation because those are the types that can be caused by a nucleotide-pair substitution like this one.

c) It could cause a nonsense mutation because the sequence would no longer be the same, so the protein would be shorter and non-functional.

d) It could cause a silent mutation because A and T are complementary to each other so it is not really a substitution mutation.

Part C

Why is a frameshift missense mutation more likely to have a severe effect on phenotype than a nucleotide-pair substitution missense mutation in the same protein?

a) A substitution missense mutation causes the protein to be shorter and thus non-functional.

b) A frameshift missense will cause the codons to be out of order, but a substitution missense does not change the order of the codons.

c) A frameshift missense mutation will cause an early Stop codon, but a substitution missense might be silent.

d) A substitution missense affects only one codon, but a frameshift missense affects all codons downstream of the frameshift.

Part D

Which of the following sequences shows a frameshift mutation compared to the wild-type mRNA sequence?

a) wild-type	5â-AUGCAUACAUUGGAGUGA-3â
mutant	5â-AUGCAUACAGAGUGA-3â

b) wild-type	5â-AUGCAUACAUUGGAGUGA-3â
mutant	5â-AUGCAUACGUUGGAGUGA-3â

c) wild-type	5â-AUGCAUACAUUGGAGUGA-3â
mutant	5â-AUGCAUACAUCUGGAGUGA-3â

d) wild-type	5â-AUGCAUACAUUGGAGUGA-3â
mutant	5â-AUGCAUGUGACAUUGGAGUGA-3â

Part F

Suppose that the triplet of nucleotides indicated in bold (AGC) spans two codons, that is, CTA and GCC. If the triplet AGC were deleted from this DNA coding sequence, what effect would it have on the resulting protein?

5â-ATGCTAGCCTATCGTAAC-3â

a) The two flanking codons would be altered, but the rest of the amino acid sequence would be the same because there would be no frameshift.

b) The entire amino acid sequence would be altered due to the frameshift.

c) All of the amino acids after the deletion would be altered due to the frameshift.

d) All of the amino acids up to the deletion would be altered due to the frameshift.

mauvetrout554

1) a mutation occurs in which an AAA codon, which signifieslysine, into AGA which signifies a chemically similar amino acidarginine. This is an example of a ____ mutation?

a) conservative nonsynomous b) frameshift c)nonsense d) conditional e) silent

It has to be neutral mutation, but the option for neutral is notgiven... would it be conditional?

2) Which of the following types of inheritance could account foran affected male having all affected daugters but no affectedsons?

a) autosomal recessive b) autosomaldominant c) Y-linked d) X-linkedrecessive e) X-linked dominant

it has to be dominant... so its either b or e?

3) The site where RNA polymerase binds to the DNA template iscalled the ____ sequence.

	a)	enhancer
	b)	promoter
	c)	domain
	d)	terminator
	e)	reading frame

peardinosaur896

1. Gennie is wild type. Below is a segment of her DNA. The topstrand is the coding region, and the reading frame begins with thefirst codon that codes for met (start codon).

5' GCATGTTCTTGT 3'

3' CGTACAAGAACA 5'

Kevin is mutant. Below is a segment of his DNA. The top strandis the coding region, and the reading frame begins with the firstcodon that codes for met (start codon).

5' GCATGTTTTTGT 3'

3' CGTACAATAACA 5'

What type of mutation does Kevin have?

A) silent

B) misssense

C) nonsense

D) frameshift

2) A type of dwarfism results from the production of mutantSHR-1 protein. You look at the length of the mutant SHR-1 and thenormal (wild-type) SHR-1 protein, and discover that the mutantSHR-1 protein has fewer amino acids.

What do you expect to find when you examine the DNAsequence?

A) nucleotides were deleted

B) additional nucleotides were added

C) one nucleotide was changed

D) without additional information, any of the above arepossible.

3) Below are two DNA coding strand sequences. The 5' ATG encodesthe in-frame strat codon.

Tom's DNA sequence is:

5' ATG CGC TTA CCC TTA CTC CTA TAA 3'

Harry's DNA sequence is:

5' ATG CGC TAA CCC TTA CTC CTA TAA 3'

Harry's mutation causes the premature termination of:

A) Replication

B) Transcription

C) Translation

D) Answer B and C

E) All of the above

carmineoyster108

BIS 2A Midterm: Key practice midterm 3

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