CH 461 Study Guide - Midterm Guide: Random Coil, Alanine, Arrow Pushing

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In studying for the midterm, be sure that you understand and can work all of the problems on problem sets 1-3 and quizzes 1-3. Midterm 1 covers lectures 1-9, (thermodynamics through helix-coil transition) and so includes the topics described below. Equations and the value of the idea gas constant will be provided. You will need a calculator, although the use of a calculator for anything but calculations (e. g. storage of notes or structures) will be considered cheating. Calculation of free energy and standard free energy changes. Relationship between the number of configurations of a state and its entropy. Relative configurational entropy of folded and unfolded proteins. Solvation of charged, polar and non-polar solutes by water. Structures, three letter and one letter abbreviations of the twenty common amino acids. Which amino acids are acidic, and which are basic (know the predominant protonation state at ph 7. 0) Chirality of the alpha carbon; l-amino acids (corn mnemonic)