MCB 181L Study Guide - Midterm Guide: Tumor Suppressor Gene, Tonsillectomy, Germline Mutation
28 Aug 2018
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Lab section 54: james breeland and melanie clearwater have a mutation in the tp53 gene. Tp53 codes for tumor protein p53 which acts a tumor suppressor. Lfs is a predisposition to multiple cancers and has been abundant in bone cancers, brain tumors, and breast cancer. The mutation prevents p53 from regulating the uncontrollable growth and division of some cells. Melanie is likely to develop breast cancer and james osteosarcoma: both patients have had tumors and family members with tumors. Because of the presence of tumors in family members, the tumor is most likely from a germline mutation. One of the most common mutations leading to increased cancer risks is the. A tonsillectomy leads to an increased risk in breast cancer, which melanie"s mom and sister had. Melanie"s lump on her breast, two family members having breast cancer, a mutation in the tp53 gene, and an increased risk for breast cancer from her tonsillectomy, she most likely has breast cancer.
